‘Grey’s Anatomy’ Cast Departures: From Yang To Schmitt & More
‘Grey’s Anatomy’ Cast Departures: From Yang To Schmitt & More

Grey’s Anatomy has had to say goodbye to many a main character after running for 22 seasons.
From tragic deaths of beloved doctors to shocking departures of actors and actresses welcomed into the fold of Seattle Grace Mercy West Hospital, later renamed Grey Sloan Memorial Hospital, in the Shonda Rhimes-created medical drama series.
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Find the actors and actresses who have left the show and what characters they played below:
Sandra Oh as Dr. Cristina Yang
Sandra Oh portrayed Dr. Cristina Yang from 2005 to 2022 on the medical series.
Patrick Dempsey as Dr. Derek Shepherd aka ‘McDreamy’
Patrick Dempsey played Dr. Derek Shepherd on Grey’s Anatomy from 2005 to 2022.
T.R. Knight as Dr. George O’Malley
T.R. Knight played Dr. George O’Malley from 2005-2022.
Eric Dane as Dr. Mark Sloan aka ‘McSteamy’
Katherine Heigl as Dr. Izzie Stevens
